Cell signalling / Pathophysiology
نویسندگان
چکیده
منابع مشابه
Purinergic signalling: pathophysiology and therapeutic potential.
The article begins with a review of the main conceptual steps involved in the development of our understanding of purinergic signalling, including non-adrenergic, non-cholinergic (NANC) neurotransmission; identification of ATP as a NANC transmitter; purinergic cotransmission; recognition of two families of purinoceptors [P1 (adenosine) and P2 (ATP/ADP)]; and, later, cloning and characterisation...
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Upon engagement of the TCR by antigen presented on major histocompatibility complex (MHC) molecules, the Src family kinase Lck is activated and proceeds to phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs) on the ε, δ, γ and ζ subunits of the TCR. Phosphorylated ITAMs promote the recruitment and subsequent activation of another tyrosine kinase ZAP-70. Two known substrates of...
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Diverse extracellular signals are coupled at the plasma membrane to intracellular signal transduction pathways and the cytoskeleton. Members of a ubiquitous multidomain family of proteins, the MAGUK proteins, are emerging as common mediators of this coupling.
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Emerging evidence indicates that complex spatial gradients and (micro)domains of signalling activities arise from distinct cellular localization of opposing enzymes, such as a kinase and phosphatase, in signal transduction cascades. Often, an interacting, active form of a target protein has a lower diffusivity than an inactive form, and this leads to spatial gradients of the protein abundance i...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2012
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfs213